Tegaserod: what's old is new again

GS Sayuk, J Tack - Clinical Gastroenterology and Hepatology, 2022 - Elsevier
… the gastroenterologist a comprehensive summary of the … Cisapride was introduced worldwide
in the 1990s as a serotonin 5-… this withdrawal of tegaserod was a report by the Swiss drug

Tegaserod for the treatment of irritable bowel syndrome

VN Madia, A Messore, F Saccoliti… - Anti-Inflammatory & …, 2020 - ingentaconnect.com
… Results: Tegaserod was withdrawn in 2007 due to increased … and mucosal application of
serotonin activates local reflex … a concise summary of the abovementioned drugs used for …

[HTML][HTML] Efficacy and safety of 5-HT4 receptor agonist minesapride for irritable bowel syndrome with constipation in a randomized controlled trial

S Fukudo, M Nakamura, T Hamatani… - Clinical …, 2021 - Elsevier
… We did not measure lower gastrointestinal motility directly in … by treatment group using summary
statistics for baseline, each … Tegaserod was withdrawn because of its association with an …

Targeted pharmacotherapy of irritable bowel syndrome

A Arokiadoss, HC Weber - Current Opinion in Endocrinology …, 2021 - journals.lww.com
Tegaserod appeared as safe as other drugs for IBS-C in … adverse event, resulting in study
drug discontinuation in 6.5% and 0.7… opioid receptors, gut serotonin receptors, secretagogue …

Pharmacotherapeutic advances for chronic idiopathic constipation in adults

G Bassotti, P Usai Satta, G Berti, M Lai… - Expert Opinion on …, 2022 - Taylor & Francis
… [Citation52], was withdrawn from the market after the report of … of tegaserod [Citation54]
led to a new approval of the drug … agents to treat gastrointestinal motility disorders [Citation66]. …

An ex vivo study to evaluate the effect of tegaserod on platelet activation and aggregation

PA Gurbel, K Bliden, SD Barnett, C Witt… - Journal of …, 2021 - journals.sagepub.com
… for the treatment of functional motility disorders of the … on platelet aggregation induced by
ADP and serotonin plus … Following the voluntary withdrawal of tegaserod due to potential CV …

Natural polyphenols for the prevention of irritable bowel syndrome: Molecular mechanisms and targets; a comprehensive review

NM Roudsari, NA Lashgari, S Momtaz… - … of Pharmaceutical …, 2019 - Springer
… improvement, such as Tegaserod (5-hydroxytryptamine4 (5-… selective serotonin reuptake
inhibitors (SSRIs) and serotonin–… strong laxative and improves the gastrointestinal motility [86]. …

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome

DH Vasant, PA Paine, CJ Black, LA Houghton… - Gut, 2021 - gut.bmj.com
… or secondary care, but careful explanation as to the rationale for their … motility may be
influenced by alterations in serotonin (5-… Removal of the reacting antigen from the diet improved …

Bloating and abdominal distension: exploring hidden depths and insights

N Pichetshote, A Rezaie - Current Treatment Options in Gastroenterology, 2020 - Springer
… lack a clear pathophysiology explanation and an effective management … Neurotransmitters
such as serotonin via 5-… Tegaserod was withdrawn from the market in 2007 due to possible …

Pharmacologic, dietary, and psychological treatments for irritable bowel syndrome with constipation: cost utility analysis

ED Shah, JK Salwen-Deremer… - MDM Policy & …, 2021 - journals.sagepub.com
… Tolerability was defined as discontinuation of treatment due … sufficient cost data to include
tegaserod or tenapanor in this … Scholar Award in Functional GI and Motility Disorders, which …